A 3-0 home defeat by AC Milan last month has prevented Celtic from qualifying for the last 16 of the UEFA Champions League, and also ensured Neil Lennon’s side will finish bottom of Group H.
With no European football in prospect in the spring, Celtic will at least hope to put on a spirited performance against the Spanish champions.
The Bhoys have yet to win in four previous visits to the Nou Camp, but Scottish rivals Dundee United recorded a famous victory at the stadium in 1987 when beating Barcelona 2-1 in the quarter-finals of the UEFA Cup.
A Cesc Fabregas goal settled the meeting at Parkhead in October when Scott Brown was sent off for a challenge on Brazilian attacker Neymar.
Brown returns from suspension for Wednesday’s game, with Celtic looking to transfer their domestic goalscoring form to the European stage after putting five past Motherwell last Friday.
Lennon’s side have drawn a blank in four of their five group games to date, and that includes away defeats at the hands of AC Milan and Ajax.
Barcelona go into the game knowing a point will guarantee first spot after a minor dip in form over the past fortnight.
A 2-1 loss away to Ajax inflicted the first defeat of Tata Martino’s reign and that was followed up by a 1-0 reverse at Athletic Bilbao in La Liga.
Martino rested a host of key players for last Friday’s 4-1 victory at Cartagena in the Copa del Rey and he is calling for a quick tempo against Celtic.